India is once again witnessing a sudden increase in the number of Kovid-19 cases. As per the update issued by the Union Ministry of Health on Wednesday morning, there is an increase of 2,927 Kovid-19 cases and 32 deaths in one day in India today. New cases are 17 percent higher than yesterday’s figures. Is India heading for the fourth wave? The new type of Covid-19 has quickly gained a foothold in India.Also read – Rising Covid Cases Stimulate Fourth Wave Fear: Recent Mask Wearing List
Descending from the previous super-infectious stealth omicron, the new type spreads even faster than stealth omicron. Some people who were vaccinated against COVID-19 in India were later diagnosed with COVID-19. Wondering how this is possible? One possible answer is that antibodies fighting the original virus may be weaker against the highly contagious type. Also read – Covid-19: Gurugram alert after more than 400 new cases were reported in the city for the first time since February. Strict measures were imposed
Researchers at Johns Hopkins found that when fully vaccinated and boosted people produce high levels of antibodies that work against the underlying strain of SARS-CoV-2, the same small defenders do enough to prevent omicron strains from invading healthy cells. Not a good university in the US. Also read – Dehradun has made masks mandatory amid increasing cases of covid, violators will have to pay a. 500 fine. Deets inside
“Previous research has shown that vaccine-induced antibodies respond to the underlying strain of SARS-CoV-2 by inhibiting the virus’s ability to bind to angiotensin-converting enzyme 2. [commonly known as ACE2]The receptor on the surface of the cell through which SARS-CoV-2 enters, “said Joel Blanks, professor of medicine at the university’s School of Medicine.
“Our study suggests that the same antibodies produce low ACE2 inhibition with omicron strain, which opens the door to success in covid-19 infections,” he added.
For the study, published in the Journal of Clinical Investigation Insight, Blankson and team analyzed both humoral (SARS-CoV-2 specific antibodies circulating in the bloodstream and produced by B lymphocytes or B cells) and cellular (direct attack). T lymphocytes, or viruses by T cells) Immune reactions in 18 healthy and fully vaccinated people who successfully experienced infection 14 to 92 days after receiving the covid vaccine booster.
The humoral and cellular immune responses of participants with progressive infection were compared with a control group of 31 participants aged 21 to 60 years who also received covid vaccination and booster, and had no previous infection with SARS-CoV-2.
“When we tested the SARS-CoV-2 spike protein binding antibody-mediated inhibition with ACE2, we found that in the serum of study participants who succeeded in COVID-19 – possibly the result of an omikron infection – there were antibodies that strongly binded to the root. Were. The strain virus is as expected, but it did not work when responding to the Omicron strain, “said Blanks.
Levels of antibodies that inhibit spike protein binding to ACE2 – higher for the original strain virus but lower for omicon – were similar for both successfully infected participants and those in the control group.
“The relatively strong T cell response to the original and omicron strains may explain why people who succeed in the Covid-19 case usually experience only mild symptoms during their illness,” Blanks explained.
(With input by IANS)
