Scientists Discover That a Certain Nutrient Promotes Anti-Aging

According to the study, the amino acid taurine could be used in anti-aging therapies.

Our cells produce potentially toxic byproducts known as “free radicals” when they break down the oxygen we breathe and the food we eat every day in order to exist. Some of these molecules carry out important biological functions, but if there are too many, internal cell structures can be damaged, impairing the cells’ ability to function and possibly resulting in chronic disease. We refer to this process as oxidative stress.

Our bodies have a remarkable arsenal of antioxidant enzymes that help maintain a healthy balance of reactive oxygen species, but as we age, these control mechanisms decline. A recent study published in the journal Nutrition suggests that supplementing the diet with the amino[{” attribute=””>acid taurine could be a realistic approach to address the issue.

The study reported in the study was carried out at the University of São Paulo (USP) in Brazil. It involved 24 female volunteers aged 55 to 70. They were randomly separated into two groups. One group consumed three 500 mg capsules of taurine per day for 16 weeks (1.5 g per day). The other group received pills that simply contained corn starch (placebo). Neither the volunteers nor the researchers were aware of which group each participant belonged to.

Oxidative stress markers were analyzed in blood samples taken before and after the intervention. One of the most intriguing findings was an almost 20% rise in levels of the antioxidant enzyme superoxide dismutase (SOD) in the taurine group, compared to a 3.5% drop in the control group. SOD, the scientists explain, protects cells from the harmful reactions of the superoxide radical.

“Preventing the buildup of free radicals that naturally occurs with aging probably prevents cardiovascular disease, diabetes, and high blood pressure, among other chronic conditions,” said Ellen de Freitas. Freitas is a professor at the Ribeirão Preto School of Physical Education and Sports (EEFERP-USP) and co-principal investigator for a project supported by FAPESP.

According to Freitas, very few studies of the effects of taurine in the context of aging can be found in the scientific literature. “This study was a first step, aimed at investigating the ideal dose and possible side effects, none of which was observed in any of the participants,” she said.

Anti-aging therapy

Taurine is a nutrient found in certain foods, such as fish, shellfish, chicken, turkey, and beef. Additionally, it is naturally produced in some tissues of the human body, particularly the liver, and is important to the functioning of the central nervous system, immunity, eyesight, and fertility.

The Freitas group has been studying taurine’s antioxidant and anti-inflammatory properties for at least 10 years, initially in high-performance athletes and later in obese people, with daily dosages ranging from 3 g to 6 g. “The results showed that oxidative stress in these individuals could be controlled when their diet was supplemented with this amino acid. We then decided to test the strategy in the context of aging. This was very novel, so we began with a very low safety dose,” Freitas said.

The initial plan was to look at the effects of taurine supplementation in conjunction with exercise training, as well as both treatments separately. Physical activity is thought to be one of the main ways to regulate levels of oxidizing substances and antioxidants in the body, and the proper amount is thought to enhance the benefits of taurine. However, because of the pandemic and the fact that the volunteers were in a high-risk group for COVID-19 complications, the researchers chose to solely proceed with the nutritional component of the study, which could be monitored remotely.

Two other markers of oxidative stress were analyzed besides SOD: the antioxidant enzyme glutathione reductase (GR), which decreased significantly in both groups, and malondialdehyde (MDA), which increased 23% in the control group and decreased 4% in the taurine supplementation group.

“These results were modest, but we believe a higher dose of taurine could produce stronger evidence for its benefits,” Freitas said.

For Gabriela Abud, the first author of the article and currently a Ph.D. candidate at the Ribeirão Preto Medical School (FMRP-USP), changes in the volunteers’ diet in the early months of the pandemic owing to lockdown may have affected the results of the biochemical analysis.

“In addition to markers of oxidative stress, we analyzed levels of minerals such as selenium, zinc, magnesium, and calcium, which are important to the functioning of these enzymes,” Abud explained. “Selenium, for example, is a co-factor for glutathione peroxidase [which indirectly helps eliminate hydrogen peroxide from the organism] and it was reduced in both groups.”

For Freitas, taurine supplementation is just the “icing on the cake” and cannot work miracles on its own. “A healthy lifestyle with a balanced diet and regular exercise is essential for the anti-aging effect to occur,” she said.

In the next study, the group plans to include obese women between the ages of 60 and 75 with sarcopenia, a gradual loss of muscle mass that can be exacerbated by chronic inflammation. “These people face an acute risk of developing complications. We will offer physical training associated with taurine supplementation at a rate of 3 g per day and we will observe the possible alterations due to these interventions”, said Freitas.

It is important to note that the benefits and risks of dietary taurine supplementation are still under investigation. Food supplements should not be taken without medical supervision.

Reference: “Taurine as a possible anti-aging therapy: a controlled clinical trial on the antioxidant activity of taurine in women aged 55 to 70 years” by Gabriela Ferreira Abud M.Sc., Flavia Giolo De Carvalho Ph.D., Gabriela Batitucci Ph .D., Sofia Germano Travieso B.Sc., Carlos Roberto Bueno Junior Ph.D., Fernando Barbosa Junior Ph.D., Julio Sergio Marchini Ph.D. and Ellen Cristinide Freitas Ph.D., June 11, 2022, Nutrition.
DOI: 10.1016/j.nut.2022.111706