<img src="https://scx1.b-cdn.net/csz/news/800a/2022/scientists-identify-dr.jpg" alt="Los científicos identifican un fármaco que imita los efectos del ejercicio en los músculos y los huesos" title="LAMZ aumenta los músculos y los huesos al imitar la señalización del calcio para inducir PGC-1α. Esquema de la función LAMZ en el aumento de músculo y hueso. El ejercicio aumenta la concentración de calcio en las células musculares y óseas, lo que induce la señalización del calcio. Bajo esta señalización, PGC-1α y Mef2c se activan y recíprocamente impulsan su expresión. También se inducen genes mitocondriógenos, miogénicos y osteogénicos, que juntos aumentan el músculo y el hueso. Por lo tanto, LAMZ facilita la vía de señalización del calcio y restaura la aptitud locomotora. Crédito: Bone Research (2022). DOI: 10.1038/s41413-022-00225-w” width=”800″ height=”530″/> LAMZ increases muscle and bone by mimicking calcium signaling to induce PGC-1α. Schematic of LAMZ role in muscle and bone augmentation. Exercise increases the concentration of calcium in muscle and bone cells, which induces calcium signaling. Under this signaling, PGC-1α and Mef2c are activated and reciprocally drive their expression. Mitochondriogenic, myogenic, and osteogenic genes are also induced, which together increase muscle and bone. Therefore, LAMZ facilitates the calcium signaling pathway and restores locomotor fitness. Credit: bone research (2022). DOI: 10.1038/s41413-022-00225-w
Maintaining a regular exercise routine can help you look and feel great, but did you know that exercise also helps maintain your muscles and bones? People who cannot perform physical activity experience weakening of the muscles and bones, a condition known as locomotor frailty. Recently, researchers in Japan identified a new drug that can help treat locomotor frailty by inducing exercise-like effects.
Physical inactivity can result in a weakening of the muscles (known as sarcopenia) and bones (known as osteoporosis). Exercise dispels these weaknesses, increasing muscle strength and promoting bone formation while suppressing bone resorption. Nevertheless, exercise therapy cannot be applied to all clinical cases. Drug therapy may be helpful in treating sarcopenia and osteoporosis, especially when patients have cerebrovascular disease, dementia, or are already bedridden. However, there is no single drug that addresses both problems simultaneously.
In a new study published in bone researchResearchers at Tokyo Medical and Dental University (TMDU) developed a new drug screening system to identify a compound that mimics the changes in muscle and bone that occur as a result of exercise. Using the detection system, the researchers identified the aminoindazole derivative locamidazole (LAMZ). LAMZ was able to stimulate the growth of muscle cells and bone-forming cells (osteoblasts), while suppressing the growth of bone resorbing cells (osteoclasts).
When LAMZ was given to mice orally, it was successfully transmitted into the blood, with no obvious side effects. “We were pleased to find that LAMZ-treated mice exhibited increased muscle fiber width, increased maximal muscle strength, increased rate of bone formation, and decreased bone resorption activity,” says lead study author Takehito Ono.
The research team further addressed the mode of function of LAMZ and found that LAMZ mimics the calcium and PGC-1α signaling pathways. These pathways are activated during exercise and stimulate the expression of downstream molecules that are involved in the maintenance of muscle and bone.
The TMDU-led team asked if LAMZ can treat locomotor frailty, LAMZ was administered to an animal model that has sarcopenia and osteoporosis. “Both oral and subcutaneous administration of the drug improved the muscle Y bone of mice with locomotor frailty,” says lead author Tomoki Nakashima.
Taken together, the research team’s findings show that LAMZ represents a potential therapeutic approach for the treatment of locomotor frailty by mimicking exercise.
Takehito Ono et al, Simultaneous Muscle and Bone Augmentation by Locomymetry via Calcium-PGC-1α Signaling, bone research (2022). DOI: 10.1038/s41413-022-00225-w
Provided by Tokyo Medical and Dental University
Citation: Scientists identify drug that mimics effects of exercise on muscle and bone (September 13, 2022) Retrieved September 13, 2022 from https://medicalxpress.com/news/2022-09-scientists-drug -mimics-effects-muscle.html
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