Diabetes is one of the leading medical conditions affecting people of all age groups. It can put people at risk for a number of health problems, including kidney disease, nerve and eye damage, and skin problems. Now researchers have looked at how fatty tissue from different parts of the body can lead to the onset of diabetes in men and women.Also read – Stress levels remain high between unlocked phases: Survey
The study’s findings were published in the journal Obesity Reviews. Also read – Explained: What is Covid-19 booster dose? Which vaccine will be given? Here’s what you need to know – see
Concordia researchers Carrie Delaney and Sylvia Sentosa looked at how adipose tissue from different parts of the body can lead to the onset of diabetes in men and women. They reviewed nearly 200 scientific papers seeking a deeper understanding of how fat works on the surface and at the tissue level and how that tissue contributes to the onset of diabetes. Also read – Researchers are finding new ways to treat asthma symptoms caused by seasonal allergies
“There are many different theories about how diabetes develops, and the positives we explore show that different regions of adipose tissue contribute differently to disease risk,” said Carrie Delaney, PhD candidate at Concordia Performance Center and lead author of the paper. . “So the big question is, how do different depots contribute uniquely to its development, and are these contributions different between men and women?”
Men and women store fat in different places. Diabetes, like many other diseases, is closely related to abdominal fat. Women store fat just under the skin. This is known as subcutaneous fat. In men, abdominal fat is stored around the limbs. This is intestinal fat.
Fat shows different symptoms in men and women. They grow differently, disintegrate differently, and interact differently with inflammation and the immune system.
In men, for example, fat cells expand as fat cells grow in size; In women, fat cells multiply and increase in number. This is replaced by a loss of the protective hormone estrogen which disappears with menopause and may explain why men are more susceptible to diabetes earlier in life than women.
Researchers then examined the paper to see what was happening in the cell-level microscopic environment, working on the hypothesis that increased risk of diabetes was due to the expansion of intestinal fat in men and subcutaneous fat in women.
Despite the need for further research, overall differences in immune cell, hormone and cell signaling levels were found in men and women that support different origins in interstitial diabetes.
Delaney and Sentosa hope that by recognizing how the risks of diabetes differ between men and women, clinical approaches to treating the disease can be better defined between species.
“Currently, the treatment for diabetes is the same for men and women,” said Sentosa, associate professor in the Department of Health, Kinesiology and Applied Physiology. “If we understand the differences between them better, we can consider these methods to recommend treatment to men and women based on how diabetes drugs work.”
(ANI)
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