Blood clots can form when the wound is healing. This is according to a new study by RCSI University of Medicine and Health. The research was published in the journal Science Advances.Also read – Study 7 suggests official climate friendly dietary guidelines
The research examined the behavior of platelets at the Ghanaian site, specifically their ability to understand where they are inside the blood clot and regenerate the environment around them accordingly. Also read – World Thrombosis Day 2021: Thrombosis, Symptoms, Treatment Explained | Watch the video
Platelets are the key to wound healing and the formation of blood clots (thrombus). Fibroblasts are connective tissue cells that are needed for the later stages of wound healing. Fibroblasts invade clots that form and produce important proteins, including fibronectin, which then build up the structure to make new tissue needed for healing. Also read – Covid-19 has a higher risk of blood clots than Covid-19 vaccination: a study
This new study suggests that platelets may also form a temporary fibronectin matrix in the area around them, as do fibroblasts in the later stages of wound healing. These have potential implications for how blood clotting integrity can be maintained during vascular repair.
The lead author of the study is Dr. of the School of Pharmacy and Biomolecular Sciences at RCSI. Ingmar was Shawn.
Commenting on the discovery, Dr. “We’ve identified an additional unexpected role for the most prominent platelet adhesion receptor,” said Shawn. Our results show that platelets can not only form clots but also begin remodeling by forming a fibrous scaffold. This finding challenges some of the existing patterns in the field of wound healing, dominated by research on fibroblasts. “
The key to this research was the use of super-resolution microscopy, which enables sharp images of structures inside or around cells to be captured and observed in vitro in the laboratory. To further develop this discovery it will be necessary to observe this behavior of platelets in living organisms (in vivo).
“Without super-resolution microscopy, this discovery would not be possible,” Dr. Shaw noted.
(With ANI inputs)
