For a long time, scientists did not believe that oral glutathione supplements were effective in increasing glutathione levels due to low bioavailability (and therefore bioefficacy). mbg vice president of scientific affairs Ashley Jordan Ferira, Ph.D., RDNshares that “the glutathione smear campaign really took off, but it was categorically wrong. Well-designed research just needed to catch up.”
In fact, a groundbreaking 2015 clinical study of the European Journal of Nutrition demonstrated that a specific form of oral glutathione supplement called Setria® can increase blood levels and stores of glutathione in body compartments when taken daily.* As Ferira explains, “This clinical trial demonstrates that key forms of glutathione do not not only bioavailable but also affecting the state of glutathione in the body. These are very important findings.”*
“Test methods and specific knowledge of glutathione have increased over the years, making some of the older studies showing that glutathione is not absorbed controversial and almost obsolete,” he explains. Danielle Citrolo, PharmacistVice President of Scientific and Regulatory Affairs for Kyowa Hakko USA (the innovator and manufacturer of Setria®).
Citrolo goes on to say that glutathione is a very unstable molecule that is rapidly eliminated from the blood and tissues, so it must be replenished daily. With Setria® Glutathione, oral glutathione stores are improved through proper absorption in the intestinal lining.*
“Previous studies did not take into account the fact that multiple doses may be necessary, as well as particular handling of the samples taken to test glutathione levels,” explains Citrolo.
Taking a supplement with 250 milligrams of Setria® glutathione, a clinically effective dose based on current science, every day (as the dose of mbg daily detox+) is an excellent way to promote sufficient glutathione levels and increase overall antioxidant activity in the body.*
In addition to taking bioavailable glutathione, there are a few other key bioactives and botanicals that support glutathione production and replenishment.
For example, supplements that include cysteine (eg, whey protein powder) or direct precursors to cysteine (particularly N-acetyl-L-cysteine, also known as NAC) may help promote glutathione production.* According to Alschuler, these specific ingredients are especially helpful in increasing overall glutathione levels because cysteine is the limiting amino acid (i.e., the slowest nutritional component) in glutathione synthesis. *
When it comes to herbal bioactives, milk thistle Contains a powerful free radical scavenging phytonutrient compound called silymarin that has been shown to modulate enzymes that metabolize glutathione and promote a healthy redox balance.* In addition, milk thistle supports the detoxification process reinforcing healthy liver function and protect liver cells from toxins.*
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