All about amyloidosis
Amyloidosis is rare when an abnormal protein called amyloid builds up in tissues and organs. When it does, it affects their shape and how they work. Amyloidosis is a serious health problem that can lead to life-threatening organ failure. Amyloid deposits can build up in the heart, brain, kidneys, spleen, and other parts of the body. A person can have amyloidosis in one or more organs.
Amyloidosis can be secondary to a different health condition, or it can develop as a primary condition. Sometimes it is due to a mutation in a gene, but other times the cause of amyloidosis is unknown.
Signs and symptoms
- Feeling very weak or tired
- lose weight without trying
- Swelling in the belly, legs, ankles, or feet
- Numbness, pain, or tingling in the hands or feet
- Skin that bruises easily
- Purple (purple) spots or bruised-looking areas of skin around the eyes
- Bleeding more than normal after an injury
- Increased size of the tongue
- Difficulty breathing
types of amyloidosis
There are different types of amyloidosis such as AL amyloidosis that affects the kidneys, spleen, heart, etc. AA amyloidosis is caused by fragments of the amyloid A protein. Transthyretin amyloidosis (ATTR) can be inherited from a family member (familial amyloidosis). There are other forms of amyloidosis, including APOA1, gelsolin, fibrinogen, and lysozyme.
Treatment
As there are different types of this rare disease, treatment is subjective. After diagnosing the disease by conducting appropriate tests, the doctor may suggest medication, chemotherapy, bone marrow transplantation, immunotherapy, pacemaker, stem cell transplantation, etc.
Men get amyloidosis more often than women. Your risk of amyloidosis increases as you get older. Amyloidosis affects 15% of patients with a form of cancer called multiple myeloma.
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