In addition to the direct implications for brain health of insufficient levels of bioactive B vitamins, homocysteine levels are also greatly affected. Without bioactive B vitamins, the conversion of homocysteine to methionine can be impaired (leading to more homocysteine than desired), which can negatively affect cardiovascular and neurological health over time.*
In a study published by the Journal of Neurology, Neurosurgery and Psychiatry, a positive association was found between elevated homocysteine levels and mood problems, indicating that below-average folate metabolism and methylation have direct implications for neurological well-being. While research on the exact mechanisms of B vitamins, brain health, neurotransmitters, and methylation is ongoing, the science is clear: healthy methylation contributes to a healthy nervous system.*
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